Bullous lesions of the skin and mucous membranes in primary amyloidosis.

Introduction Many varieties of skin lesion have been described in primary systemic amyloidosis including macules, papules, nodules, plaques and subcutaneous haemorrhages, usually petechial but sometimes larger (Brownstein & Helwig, 1970b). The association of amyloidosis with bullous lesions of the skin or oral mucosa has only rarely been reported but we have seen three patients in whom this striking manifestation was the presenting symptom and in a fourth patient bullae were a prominent feature of the clinical picture.